The Tumor Immunotherapy Discovery Engine (TIDE) has completed a variety of large-scale in vivo screens to discover novel mechanisms of resistance and enhanced sensitivity to cancer immunotherapy. We have created a data browser (tumorimmunity.org) to provide easy access to these data, enabling users to identify genes that increase or decrease the fitness of tumor cells growing in cell culture and/or growing as tumors in mice. Screens have been performed in vitro, in immunodeficient mice (NSG), immunocompetent wild-type mice (WT), and wild-type mice treated with immune checkpoint blockade therapy (ICB). This browser enables comparison of data from any of these conditions to identify genes that change tumor cell fitness in each context.

For more details about the individual screens, please visit our publications page.